© Fraunhofer IPA
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© Fraunhofer IPA
…was developed at the Fraunhofer Institute for Manufacturing Engineering and Automation in Mannheim. ⇒
It facilitates a standardized sample preparation with subsequent filtration in a closed, sterile system, based on standard labware.
A benchtop-device with four ports allows customizable process control for mechanical dissociation with special grinding consumables, yielding high quality single cell suspensions from fresh or frozen or even FFPE tissue samples, which can be used for a multitude of applications.
By employing an ideal combination of shearing and cutting forces, highly viable cells can be obtained for cytometry, further cytological and molecular analysis or cultivation.
© Fraunhofer IPA
…was developed at the Fraunhofer Institute for Manufacturing Engineering and Automation in Mannheim. ⇒
It facilitates a standardized sample preparation with subsequent filtration in a closed, sterile system, based on standard labware.
A benchtop-device with four ports allows customizable process control for mechanical dissociation with special grinding consumables, yielding high quality single cell suspensions from fresh or frozen or even FFPE tissue samples, which can be used for a multitude of applications.
By employing an ideal combination of shearing and cutting forces, highly viable cells can be obtained for cytometry, further cytological and molecular analysis or cultivation.
© Fraunhofer IPA
The TissueGrinder is able to dissociate a great variety of tissue types in different conditions – healthy, tumorous, fresh, frozen or even FFPE.
Generating single cell suspensions from tissue samples is highly individual. With easily adaptable protocols, the TissueGrinder accomodates specific customizations for each application.
Spleen
Lymph Nodes
Liver
Kidney
Lung
Colon
Intestine
Thymus
Heart
Gut
Tonsils
Pancreas
Stomach
Brain
Urinary Bladder
Prostate
Endometrium
Ovary
Placenta
Salivary Gland
Rectum
Breast
Duodenum
Illeum
Jejunum
Thyroid Gland
Skin
Bone
Cartilage
Adipose Tissue
Muscle
Esophagus
Vessel
Cichlid Fisch
Zebrafish
Gall Bladder
Testis
Adrenal Gland
The mechanical process of the TissueGrinder matches or even outperforms the best enzymatic protocols in terms of cell yield and viability.
The mechanical process of the TissueGrinder matches or even outperforms the best enzymatic protocols in terms of cell yield and viability
Scientific references demonstrate
the utility of the TissueGrinder technology
“The TissueGrinder from Fast Forward Discoveries quite literally saved my project.
I had exhausted all possible options for dissociating fixed cancer cell spheroids for subsequent single-cell signalling studies, when I came across this product. I could hardly believe my eyes when I saw the perfect single-cell suspension generated by my demo TissueGrinder after just 3 minutes of the standard “Harsh” protocol (and with no enzymes!).
It is now an integrated part of my single-cell signalling workflows, and I dare say some of my key discoveries over the last year would not have been possible without this equipment.”
Ralitsa Madsen – UCL, Sir Henry Welcome Postdoctoral Fellow:
https://www.protocols.io/view/processing-of-fixed-spheroids-for-tobis-barcoding-c5h3y38n.html
Scientific references demonstrate
the utility of the TissueGrinder technology
“The TissueGrinder from Fast Forward Discoveries quite literally saved my project.
I had exhausted all possible options for dissociating fixed cancer cell spheroids for subsequent single-cell signalling studies, when I came across this product. I could hardly believe my eyes when I saw the perfect single-cell suspension generated by my demo TissueGrinder after just 3 minutes of the standard “Harsh” protocol (and with no enzymes!).
It is now an integrated part of my single-cell signalling workflows, and I dare say some of my key discoveries over the last year would not have been possible without this equipment.”
Ralitsa Madsen – UCL, Sir Henry Welcome Postdoctoral Fellow:
https://www.protocols.io/view/processing-of-fixed-spheroids-for-tobis-barcoding-c5h3y38n.html
Generating high quality single cells from tissue samples is a real bottleneck for many applications, such as Flow Cytometry, Single Cell Sequencing, Isolation of Primary Cells, Cancer Cell Line Development to name a few.
Conventional tissue dissociation is is either time-consuming, non-standardized, not scalable or accepting all drawbacks of enzymatic digestion. Or all of them together.
With the TissueGrinder, this bottleneck can be overcome and the door to a new level in single cell analysis can be opened wide.
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